APSU Study Updates

Neonatal and Young Infant Herpes Simplex Virus (HSV) Infection

The case definition for this study has been updated commencing for the February 2017 Report Card.

Please report any neonate or infant aged less than 3 months of age (regardless of gestation) seen in the last month with laboratory confirmation of HSV infection, and with either clinical evidence of HSV infection or laboratory confirmation of maternal perinatal HSV infection in an asymptomatic infant.

Laboratory confirmation is by detection of HSV by PCR in a surface swab**, respiratory specimen and/or sterile site (CSF or blood) (or by virus isolation), or by immunofluorescence

Clinical evidence of neonatal HSV infection is one or more of: typical herpetic lesions of the skin, eye or mouth; evidence of disseminated infection (bleeding, bruising or coagulopathy, jaundice or elevated serum bilirubin, hepatosplenomegaly or elevated liver transaminases), pneumonitis (respiratory distress or chest radiograph) or encephalitis (lethargy, seizures, apnoeas or abnormalities on neuroimaging or EEG).

Laboratory evidence of maternal perinatal HSV infection will be by detection of HSV in maternal genital swab and /or mother seroconverted to HSV or IgM positive in pregnancy or early postnatal period.